13 April 2008

Hormones and Gender/Sexuality

I'd like for someone to confirm or correct my theory.

The way I see it. An embryo is initially genderless. In about 6 weeks, the body has produced germ cells that can turn into sperm or eggs. The body has everything it needs to be either male or female; even both male and female hormones. This is why men have nipples and women have a clitoris.
The genes start giving instructions to the gonads. If you have a Y chromosome, the SRY gene will turn on and tell your body to produce a lot of androgens. These androgens act on your gonads, degenerating the ducts that would create the uterus and growing the ducts that will create the testes.
If you have two x chromosomes, your body will create female genitalia because there are not enough androgens to promote male genitalia.
More importantly, androgens also affect brain development.
So in actuality, the only function of genetics is to tell your body what hormones to promote and when.

If you have a y chromosome and something blocks the process (not enough androgens are produced or they are not produced at the right time), you may develop female genitalia.
If you have a x chromosome and somehow androgens are introduced into your body (maybe from your mother), you may develop male genitalia. Both of these situations are more likely to cause intersex conditions.
I'll also fit sexual orientation in the equation. That a slight or gross variation in the what, when, where, and how much can affect our sexual orientation.

So taking hormones actually does a lot to reverse the process from MTF or FTM. I've heard that the traditional male and female thought patterns (motor skills and emotional response) change when people are on hormones.

The reason we don't completely turn into the opposite sex is because of timing. Sexual development in utero is timed pretty precisely. I also think hormone balance before and during puberty is key to sexual development.

This leads me to believe that male and female are two extremes at the ends of a broad spectrum or continuum. It's why no two vaginas are alike and not all penises are the same size. Everyone doesn't identify with the genitalia they were born with and Everyone isn't exclusively attracted to the opposite sex.

Hormones are the primary controller of biological sex. I think it's a lot more than we realize. I think they determine anything that has to do with gender and sexuality.

I think gene expression is very complex. It is amazing that a gene would turn on, turning on other genes and give instructions that tell your body how much hormones to produce and when.
My idea is that genetic control could be overridden by artificial introduction of hormones.

Chemistry is not an exact science. There is great variation in chemical reactions. I believe if you mix two substances, the product is never exactly the same mixture. This may be true of hormones. Timing and "dosage" are crucial. Any variation of either would explain spectrum between two extremes.

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